RxC International’s experience in the Age-related Macular Degeneration (AMD) market has driven us to ask key questions about future products in the wet AMD market.  We collaborate with our clients to identify the best pathway for development and commercialization. 


Wet AMD is preceded by dry AMD where, in some cases, abnormal blood vessels invade the cornea and is the leading cause of blindness for people over 55 years of age.  Currently two approved treatments (Lucentis and Eylea) are available and HCPs have been prescribing Avastin off-label in the US and around the world and is preferred due to the low cost.  Though recent combination (anti-VEGF and anti-PDGF) therapies have failed, there are other therapies under development to offer more efficacious and less frequent dosing options.

Key Questions for Wet AMD Product Development

  • How effective are these next generation Wet AMD therapies that offer more effective and convenient treatment choices?
  • How to develop treatment strategies to adjust frequency of dosing?
  • How to develop biomarkers to track disease progression?
  • How to address remaining unmet needs (not all patients respond well and some are turning into refractory patients for current treatments)?
  • How to develop and offer personalized therapies in wet AMD to increase treatment effectiveness and patient engagement for best outcomes?
  • What life cycle management opportunities exist?  How best to capitalize on these opportunities?


    About RxC International

    RxC International has done significant work in wet AMD to address the questions above.  These projects range from strategic market assessments to life cycle opportunities to valuation of assets in AMD therapeutic areas.  To learn how we can assist your company with developing and commercializing wet and dry AMD therapies, please contact us.